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diseased human lung fibroblasts, ipf  (Lonza)


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    Lonza diseased human lung fibroblasts, ipf
    Diseased Human Lung Fibroblasts, Ipf, supplied by Lonza, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+ipf+lung+fibroblasts/idiopathic+pulmonary+fibrosis+human+lung+fibroblasts++ipf+hlf/10__1021_slash_acsptsci__5c00009-172-0-9
    Average 90 stars, based on 1 article reviews
    diseased human lung fibroblasts, ipf - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.
    Article Snippet: We describe the discovery and preclinical characterization of a potent and selective lysophosphatidic acid receptor 1 (LPAR1) antagonist with a direct-acting antifibrotic mechanism.. 18a was initially identified as a potent non-carboxylic acid LPAR1 antagonist in an LPA-induced myocardin-related transcription factor A (MRTF-A) nuclear translocation assay.. Modifications to the aromatic elements in the structure allowed for improvements in metabolic stability and the mitigation of GSH adduct formation, but in vitro to in vivo clearance disconnects were observed with several potent sulfonamides (e.g., 27b) across preclinical species.



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